Abstract: Objective To investigate the application of FX60 dialyser on chronic complications in maintenance hemodialysis patients. Methods A total of 30 patients aged from 28 to 78 years old and on hemodialysis for more than 2 years were switched to FX60 dialyzer for hemodialysis for one year. Their clinical and biochemical indicators, including blood pressure, hemoglobin, albumin, intact parathyroid hormone (iPTH), calcium, lipids, calcium and phosphorus product, Kt/V and β2-MG clearance rate, were obtained before and after the application of FX60 dialyser. Results After the dialysis with FX60 dialyser for one year, hemoglobin increased from 103.9±18.1g/l to 111.8±11.5g/l (P＜0.05), iPTH declined from 525.2±695.6pg/ml to 437.3±417.2pg/ml (P＜0.05), mean arterial blood pressure lowered from 106.1±7.5mmHg to 104.5±7.3mmHg (P＜0.05), and high-density lipoprotein (HDL) increased from 0.91±0.27mmol/l to 1.02±0.28mmol/l (P<0.05). There were no significant differences in clearance rates for small molecules between low-flux dialysis and high-flux dialysis. β2-MG clearance rate was 35.9±3.8% after one dialysis session using FX60 dialyzer. Conclusion High-flux hemodialysis with FX60 dialyser effectively improves β2-MG clearance, renal anemia, hypertension, and secondary hyperparathyroidism in maintenance hemodialysis patients.

Key words: High-flux hemodialysis, FX60 dialyser, β2-microglobulin