Abstract: 【Abstract】 Objective To study the effect of hemodiafiltration on micro-inflammation and cardiac function in maintenance hemodialysis patients complicated with heart failure. Methods Fifty patients with uremic anemia and heart failure were divided into hemodiafiltration (HDF) group (n=25) and hemodialysis (HD) group (n=25). Patients in the 2 groups were treated with similar cardiotonic agents. Serum CRP, IL-6 and TNF-α were measured by immunoturbidimetry or ELISA method before the treatment and after treatment for 3 months. Their left ventricular diastolic diameter (LVDd), LVDs, interventricular septal thickness (IVST) and left ventricular ejection fraction (LVEF) were measured by echocardiogram. Result In HDF and HD groups before treatment, serum CRP, IL-6 and TNF-α were much higher than those in control group, the left ventricular end-diastolic dimension (LVEDd) and IVST increased, and the LVEF decreased remarkably (P<0.05). After the treatment, the significant amelioration rate and total effective rate were higher in HDF group than in HD group. Serum CRP, IL-6 and TNF-α decreased significantly in HDF group, but they were still higher in HD group. LVEF increased, and LVDd, LVDs and IVST decreased in HDF group, but these parameters unchanged in HD group after the treatment (P>0.05). Conclusion Cardiac function decreases apparently in hemodialysis patients complicated with heart failure. Long-term HDF removes inflammatory factors efficiently, improves cardiac function, and achieves a higher effective rate.

Key words: Micro-inflammation, Cardiac function