Objective To summarize serum albumin and C-reactive protein (CRP) levels in hemodialysis patients treated in Beijing Hospital in 2008, and to analyze their effect on patients’ prognosis. Methods We summarized serum albumin and CRP levels in 93 hemodialysis patients treated in Beijing Hospital in 2008. The patients were divided into four groups based on their serum albumin and CRP levels. Mortality rate and cause of death before the end of 2010 in each group were recorded, and a survival curve was then derived. Results (a) Patients’ serum albumin level improved following treatment. At the beginning and the end of 2008, serum albumin level was 38.42±2.81g/L and 39.41±2.77g/L (P=0.002), respectively. Serum albumin level was higher in male patients than in female patients. At the end of 2008, serum albumin was 39.56±3.26g/L in male patients and was 39.24±2.12g/L in female patients, and the level was in the normal range in 91.0% patients. The percentage of normal serum albumin was higher in the patient group of <60 years old than in the group of >60 years old (χ2=6.746，P=0.014). (b) Serum CRP level decreased following hemodialysis. At the beginning and the end of 2008, serum CRP level was 0.53±0.46mg/dL and 0.38±0.20mg/dL, respectively (t=2.276, P＜0.05). Serum CRP correlated negatively with serum albumin (r=-0.238, P＜0.01). The major causes of death in this cohort were septic shock and cardiac-cerebro-vascular diseases (82.3%). Survival analysis demonstrated that the mortality rate was 66.7% in the group with abnormal albumin and CRP levels, 50.0% in the group with abnormal albumin level, and 18.8% in the group with abnormal CRP level (χ2=72.563，P=0.000). Conclusions Patients’ serum albumin level improved following hemodialysis. Serum albumin level was higher in male patients than in female patients. The percentage of normal serum albumin was higher in the patient group of <60 years old than in the group of >60 years old. Serum CRP correlated negatively with serum albumin. Mortality rate was higher in patients with hypoalbuminemia and higher serum CRP.