Abstract: 【Abstract】 Objective A longitudinal study was performed aimed to evaluate the dynamic change of sleep disturbances and its related factors in maintenance hemodialysis patients treated in this hemodialysis center.  Methods Patients on maintenance hemodialysis for more than 3 months were recruited in this study. Sleep quality evaluation using the Pittsburgh Sleep Quality Index (PSQI) and the Epworth Sleepiness Scale (ESS) was performed twice with an interval of 15 months. Biochemical parameters were collected as well. Results (a) In the 60 patients completed the sleep quality survey at the first evaluation, the incidence of sleep disturbances was 60% (PSQI＞5) and daytime sleepiness was 58.3% (ESS＞6). (b) In the 60 patients, 55 completed the second sleep quality survey. Sleep disturbances accounted for 89% and daytime sleepiness 87.3% of the 55 patients. After comparing the scores of the two surveys, we found that the increase of PSQI and ESS scores was statistically correlated to the values of iPTH, calcium-phosphate product, CRP and Hb. Conclusion (a) Sleep quality deteriorated along with the increase of dialysis age. (b) This deterioration was related to the values of iPTH, calcium-phosphate product, CRP and Hb.

Key words: Sleep disorders, Hemodialysis, Quality of life, Calcium and phosphorus metabolism