Abstract: Objective To discuss the effect of peritoneal dialysis to C-reactive protein (CRP) of uraemic patients and the relation between inflammation and malnutrition, anemia and cardio-cerebrovascular diseases. Method Detection of C-reaction protein (CRP), serum albumin (Alb), hemoglobin (Hb)，serum creatinine（Scr）of healthy control subjects, non-dialysis uraemic patients and continuous ambulatory peritoneal dialysis (CAPD) patients, and then divide them into normal group (CRP<10mg/L) and abnormal group (CRP>10mg/L) according to the CRP level of CAPD patients. Results The CRP level of both non-dialysis uraemic group and CAPD group are higher than that of healthy control group (P<0.001) while the CRP level of CAPD group is higher than non-dialysis uraemic group（P<0.01）.The CRP level of CAPD patients is negatively associated with Alb and Hb (P<0.01),The probability to have cardio-cerebrovascular disease of elevated CRP level group is higher than normal group (P<0.05). Conclusions CAPD patients have inflammation with a rising CRP level, and this probability is higher than that of non-dialysis uraemic patients. Inflammation plays a role in malnutrition and anemia of CAPD patients, and it also has something to do with cardio-cerebrovascular disease of CAPD patients.