[Abstract] Objective To investigate the role of APD in MODS with AKI patients requiring continuous renal replacement therapies. Methods Retrospectively reviewed MODS with AKI cases treated with APD(Group A) or CVVH(Group B) from 2010 January to 2011 March. The clinical characteristics，causative of AKI，treatment modalities，and outcomes were analyzed and compared with these two groups.Results Group A and group B comprised 14 cases and 19 cases respectively. There were no significant differences between two groups in baseline clinical characteristics. Furthermore, The groups were similar in metabolic control and correction of fluid overload. BUN,serum creatinine, and bicarbonate levels were stabilized after 72h treatment procedure. Mortality was 75% in group A and 78.9% in group B(P=0.68). There was no significant difference in infectious complications rate between two groups. Cost of disposables was higher in group B than in group A.Conclusions APD may be a safe, effective and low cost alternative to renal replacement therapy in MODS with AKI.