Abstract: 【Abstract】 Objective To evaluate the effect of sustained low-efficient hemodiafiltration (SLEDF) on acute kidney injury (AKI) patients following wasp stings. Methods Clinical data of the 31 patients with phase III AKI following wasp stings were retrospectively analyzed. These patients were treated with SLEDF (SLEDF group, n=17) or continuous veno-venous hemofiltration (CVVH) (CVVH group, n=14). General conditions of the patients, mortality, time to reach polyuria stage, time to recover from higher serum creatinine, score of acute physiology and chronic health evaluation (APACHE II), serum level of creatinine at the 3rd and 7th day after treatment, adverse effects of SLEDF and CVVH, and expenses for blood purification were compared between the two groups. Results There were no significant differences in general conditions of the patients, mortality (11.7% vs 7.1%), time to reach polyuria stage (22.2±3.2 days vs. 20.2±4.1 days), time to recover from higher serum creatinine (39.3±7.9 days vs. 34.1±7.7 days), and adverse effects between the two groups. There were also no significant differences in APACHE II scores and serum creatinine levels before treatment, at 3rd day and 7th day between the two groups. Blood purification expense was lower in SLEDF group than in CVVH group (P＜0.01).  Conclusion SLEDF and CVVH have similar effects in outcomes, recovery of renal function, relief of early disease symptoms, and stabilization of hemodynamics in acute kidney injury (AKI) patients following wasp stings. However, the expense is lower in SLEDF than in CVVH.

Key words:  Sustained low-efficient hemodiafiltration, Acute kidney injury, Wasp stings