The tunneled cuffed catheter (TCC) as a kind of important vascular access, currently used to the hemodialysis patients who can not establish arteriovenous fistula or wait for its maturity. But thrombus and fiber formation is the major complication caused dysfunction in the use of catheters. Warfarin is a conventional anticoagulant and usually used for preventing thrombus embolism disease, such as treat thromboembolism sex phlebitis, pulmonary embolism and atrial fibrillation. Under the closely monitoring of INR, the effective and safety of warfarin in preventation the thrombosis and malfunction of TCC had been proved for many studies, and it could prolong the life of the catheter. This paper reviews the effect of warfarin keep free of TCC.