A male patient, aged 40 was admitted for malaise, less appetite and nausea for one week. He was diagnosed with Chronic Renal Failure, CKD stage 5 through examination after admission and hemodialysis treatment was applied. The no-heparin dialysis method was used for the first time with no adverse reactions occurring. Later the heparin anticoagulation hemodialysis was uesd and he had excruciating headaches which disappeared after two hours of hemodialysis end. After two monthes the no-heparin method of dialysis was applied again due to upper gastrointestinal bleeding and the headache disappeared. But the headache reoccurred when we used heparin again.So we conclude that the headache was related to heparin sodium. Therefore no-heparin hemodialysis has been used to sustain the patient s life so far.