Objectives To explore the diagnosis and management experiences of subclavian vein stenosis in the aged hemodialysis patients. Methods We retrospectively analyzed two cases with subclavian vein stenosis in the aged hemodialysis patients from April to July 2012, analyzed and summarized the experiences of diagnosis and treatment. Results The two hemodialysis patients with edema in upper limbs were diagnosed by venograpy, and the symptoms were resolved by simple angioplasty and angioplasty plus stent implantation. Conclusions The interventional stent implantation is a minimally invasive and efficient method for subclavian vein stenosis in the aged hemodialysis patients.