Abstract: Objective: To investigate the effect of resin-absorbed hemoperfusion on Renin-angiotensin-aldosterone system in hemodialysis patients with resistant hypertension. Methods: 64 patients in our hospital were randomly divided into 2 groups, each group has 32 cases. Each patient has 2 or 3 times dialysis for a week in the group of HD. And other group of patients received 1 time resin-absorbed hemoperfusion on the basis of conventional dialysis once a week. Observed the changes of blood pressure, renin , angiotensin II and parathyroid hormone before treatment and after 8 weeks treatment. Result: 1. The blood pressure, renin , angiotensin II and parathyroid hormone of the patients were no significant difference compared with before treatment in the group of HD. 2. After 8 weeks treatment, the blood pressure, renin , angiotensin II and parathyroid hormone of the patients in the group of HD+HP were significantly lower than before, and each index were significantly lower than the group of HD at the same tiame. Conclusion: Resin-absorbed hemoperfusion combined with hemodialysis can better control the bloodpressure and effectively reduce the levels of renin and angiotensin II of uraemia patients.

Key words: Hemodialysis, Hemoperfusion, Uremia, Intractable hypertension