Abstract: 【ABSTRACT】Objective: To explore the morbidity and the management of the chronic kidney disease-mineral and bone disorder (CKD-MBD) in maintenance hemodialysis (MHD) patients at our hospital center, to analyze the related risk factors. Methods: The target population was the 217 patients who receive treatment of hemodialysis inhemodialysis center of our hospital during Jul.2010 to Mar.2011. We gathered the demographic information and the CKD-MBD related indicators,such as serum calcium, phosphorus, PTH, Vascular calcifications were determined by lateral abdominal, frontal pelvic and hands X-rays, counted the vascular calcification scores by the method of Kauppila and finally analyzed the morbidity ,the control rate and the potential relative risk factors of the abnormalities of the indicators by the multi-variance Logistic regression analysis. Results: 217 patients were evaluable for this study; The morbidity of hyperphosphatemia, hypercalcinemia, hypocalcemia, reduced PTH and elevated PTH were 45.16%, 31.80%, 21.66%, 20.74% and 48.39% respectively. On X-rays, 154 patients (70.94% of the whole population) had evidence of vascular calcification, The proportion of patients meeting the criteria of CKD-MBD was as high as 96.31%. The percentage of patients who achieved the recommended standard levels of serum calcium, phosphorus, PTH were 45.16%、44.7% and 30.88% respectively. Only 20 patients achieved all the recommended standard levels of serum calcium, phosphorus, PTH, accounting for 9.22% of the whole population. The control rates of serum Ca and P were lower the results in DOPPS4.From the multi-variance Logistic regression analysis, The potential relative risk factors were as follows: elevated PTH: hyperphosphatemia and hypocalcemia; reduced PTH: advanced age and history of taking activated vitamin D; vascular calcification were as follows: advanced age, ALP, hyperphosphatemia and CRP. Conclusion: CKD-MBD is prevalent in MHD patients.The control rates of the CKD-MBD related targets were lower than the results in DOPPS4.

Key words: mineral and bone disorder, chronic kidney disease, calcium phosphorus metabolism, parathyroid hormone, vascular calcification