ABSTRACT Objective To investigate the effect of high flux hemodialysis on lipid metabolism and micro-inflammatory state in maintenance hemodialysis patients. Methods A total of 80 MHD patients were randomly divided into two groups :high flux hemodialysis (HFHD)group ,and low flux hemodialysis (LFHD) group .the treatment lasted 6 months .Changes of the parameters for lipid metabolism and micro-inflammatory state were observed before and after the treatment in two groups . Results After 6 months ,high sensitive creactive protein ( hsCRP)、 intact parathyroid hormone (iPTH )、triglyceride (TG)、 total cholesterol (TC)、β2-microglobulin (β2MG)、 Apolipoprotein A(APOP-A) were significantly lower in HFHD group than those in LFHD group ,and than those in HFHD group before treatment (P<0.01),while hemoglobin(HGB) were significantly higher in HFHD. The incidence of acute infection and cardiovascular events were lower in HFHD group than in LFHD group (P<0.01). Conclusions High flux hemodialysis can not only improve micro-inflammatory state and dyslipidema but also