Abstract: 【Abstract】Objective To observe the outcome of patients with severe acute pancreatitis (SAP) treated with continuous renal replacement therapy (CRRT). Methods Eighty-two hospitalized patients with SAP were treated with continuous veno-venous hemofiltration (CVVHF). Biochemical parameters and APACHE Ⅲ score were examined before and after CVVHF. The patients were divided based on the replacement rate in CRRT into 2 groups, group A (30～45ml/kg/h) and group B (45～60ml/kg/h). Respiratory rate and heart rate were recorded before CRRT and after CRRT for 24h. Results After CRRT, serum amylase, triglyceride, total bilirubin, C-reactive protein, creatinine, urine amylase decreased significantly (P＜0.05), and hypoxemia improved (P＜0.05). APACHE Ⅲ score decreased from 96.1±33.5 before CRRT to 48.9±13.7 after CRRT for 24h (P＜0.05). Sixty-five of the 82 SAP patients recovered with the survival rate of 79.3%. Respiration rate and heart rate improved better in group B than in group A (P＜0.05). Conclusions CRRT is effective for the treatment of SAP patients. It significantly improves the clinical symptoms and reduces the mortality of SAP. CRRT with higher replacement rate may be beneficial to stabilize respiration and circulation systems.

Key words: Continuous renal replacement therapy, Severe acute pancreatitis