Abstract: Objective To investigate the prevalence of anemia and the factors relating to anemia for the management of anemia and improvement of life quality in maintenance hemodialysis (MHD) patients. Methods Patients on MHD for more than 3 months in this hospital in March 2012 were recruited and observed. Their clinical and biochemical parameters were collected. Results A total of 384 patients (194 males and 190 females) with the mean dialysis age of 42.22±38.26 months were enrolled in this study. Hemoglobin (Hb) lower than the range of Hb suggested by KIDGO guideline was found in 247 patients. Urea nitrogen reduction ratio, Kt/V, blood pressure, serum K+, Ca2+, P and LDL were similar in patients with lower Hb and those with normal Hb (P＞0.05), but ALB (P=0.012), iron (P=0.018), ferritin (P =0.024), creatinine (P=0.018), uric acid (P=0.012), intact parathyroid hormone (P=0.006), alkaline phosphatase (P=0.044) were correlated to anemia. Multiple linear regression analysis found that female, lower iron concentration, and higher ferritin, intact parathyroid hormone and alkaline phosphatase were associated with lower Hb. Conclusion Maintenance of normal iron metabolism and control of secondary parathyroidism are essential to MHD patients. Whether the target Hb value should be identical in both genders is currently unknown yet, and large cohorts of MHD patients are required to understand this issue.

Key words: Hemodialysis, Anemia, Ferritin, Intact parathyroid hormone