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Chinese Journal of Blood Purification ›› 2014, Vol. 13 ›› Issue (05): 384-386.doi: 10.3969/j.issn.1671-4091.2014.05.007
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Abstract: Objective To investigate the effect of dry body weight adjustment on the pulmonary hypertension in maintenance hemodialysis (MHD) patients. Methods In the 120 uremic patients treated with MHD in our hospital in the period from March, 2012 to April, 2013, pulmonary hypertension was found in 18 cases. They had the dialysis age of more than one year (3.41±1.23 years), 12 were males and 6 were females, and the average age was 47.44±6.13 years old. The primary diseases leading to MHD were chronic glomerulonephritis in 10 cases, diabetic nephropathy in 5 cases, hypertensive benign arteriolar nephrosclerosis in 2 cases, and renal tuberculosis in one case. They were treated with conventional hemodialysis using polysulfon membrane 1.4 m2 dialyzer 3 times a week. Pulmonary artery hypertension (systolic pulmonary artery pressure ≥ 35 mmH) was estimated by Doppler echocardiography. Dry weight adjustment was conducted in patients with pulmonary artery hypertension for one month. Blood pressure, hemoglobin, serum phosphorus, parathyroid hormone, plasma brain natriuretic peptide, transverse and longitudinal diameters of right atrium, inner diameter of pulmonary artery, and pulmonary artery systolic blood pressure by echocardiography were compared before and after the dry weight adjustment. Results After the down-regulation of dry weight, pulmonary arterial pressure decreased from 48.00±8.15 mmHg before treatment to 42.00±6.75 mmHg after the treatment (P<0.05), and plasma brain natriuretic peptide concentration from 7467.8±2357.4 pg/ml to 4759.2±1367.9 pg/ml. In addition, transverse diameter of right atrium decreased from 32.19±7.93 mm before the treatment to 26.84± 4.23 mm after the treatment, longitudinal diameter of right atrium from 43.09±8.95 mm to 35.96±8.69 mm, pulmonary artery diameter from 25.18±4.06 mm to 21.64± 2.49 mm, left ventricular diameter from 56.15± 6.28 mm to 50.25±5.39 mm, and left ventricular ejection fraction increased from 43.2±12.3% to 55.3 ± 13.6%. All of these changes were statistically significant (P<0.05). The changes of blood pressure, hemoglobin, serum parathyroid hormone, calcium, and phosphate were also statistically significant as compared with those before treatment (P>0.05). Conclusion In MHD patients with pulmonary hypertension treated with the downregulation of dry weight, excessive water can be eliminated, resulting in the decreases of transverse diameter of right atrium, pulmonary artery diameter, pulmonary pressure, right ventricular diameter, the pressure on left ventricle, and left ventricular diameter, and thereby in the improvement of left ventricular function and left ventricular ejection fraction.
Key words: hemodialysis, pulmonary hypertension, dry weight
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URL: https://www.cjbp.org.cn/EN/10.3969/j.issn.1671-4091.2014.05.007
https://www.cjbp.org.cn/EN/Y2014/V13/I05/384