【Abstract】 Objective：By comparing the treatment effectiveness of coupled plasma filtration adsorption (CPFA) and high volume hemofiltration(HVHF) in patients with severe sepsis，to investigate the advantages of CPFA．Methodology：Thirty-five patients with severe sepsis were randomly divided into CPFA group(n=18) and HVHF group(n=17)．The patients received CPFA or HVHF on the basis of routine therapy．Changes of the body temperature，heart rate(HR)，mean arterial pressure(MAP)，the dose of dopamine，the oxygenation index(PaO2/FiO2)，blood routine，biochemical parameters of liver and kidney function，the electrolytes，blood lactic acid，immune globulin，complement，APACHEⅡ score，TNF-α，IL-10，HMGB-1，CRP were compared between the 2 groups before and after the treatment for 10 hours．The safety of the two kinds of treatment were simultaneously evaluated．Results：After the two therapies，the body temperature，HR，serum creatinine(Scr)，BUN，blood lactic acid，the dose of dopamine，APACHEⅡ score were all significantly decreasad，the MAP and PaO2/FiO2 were significantly increased，electrolytes and acid-base balance were well maintained，there were no statistical differences between the 2 groups(P>0.05)．After the two kinds of treatment，no visible influences were found in the 2 groups in the levels of white blood cell count，hemoglobin count，platelet count，alanine transaminase，aspartate aminotransferase，bilirubin，serum albumin，immune globulin，complement(P>0.05)．After the two therapies，the levels of TNF-α，IL-10，HMGB-1，CRP were all significantly decreased(P<0.05)，however，these changes were more evident in CPFA group than in HVHF group(P<0.05)．The two therapies were safe，and no therapy related adverse reactions such as haemorrhage，hypersensitiveness or embolism were noted during the two therapies．Conclusion：Although both CPFA and HVHF can safely and effectively adjust the internal environment of patients with severe sepsis，CPFA has better abilities in lowering levels of inflammation factors．