Abstract: 【Abstract】 Objective To explore the relationship between serum B-type natriuretic peptide (BNP) level and oxidative stress in patients on peritoneal dialysis. Methods A total of 81 patients on continuous ambulatory peritoneal dialysis (CAPD) patients and 12 healthy controls were enrolled in this study. Serum BNP and oxidative stress biomarkers including advanced oxidation protein product (AOPP), superoxide dismutase (SOD), maleic dialdehyde (MDA) were measured. Patients were divided by BNP level into 3 groups: group A (BNP＜128.63 pg/ml, group B (BNP 128.63～211.65 pg/ml), and group C (BNP ＞211.65 pg/ml). The relationship between serum BNP and oxidative stress and clinical indicators were explored. Results Serum BNP, AOPP and MDA levels were significantly higher in peritoneal dialysis patients than in healthy controls, but serum SOD level was significantly lower in peritoneal dialysis patients than in healthy controls. Serum AOPP was significantly higher in groups B and C than in group A, and was significantly higher in group C than in group B. Serum SOD was significantly lower in group B than in group A, was significantly higher in group C than in group B, and had no statistical difference between group A and group C (P＞0.05). Serum MDA was statistically indifferent among the three groups (P＞0.05). AOPP and MDA were positively correlated with BNP, but SOD was negatively correlated with BNP in CAPD patients. Conclusions Volume overload was closely related to the oxidative stress in patients on peritoneal dialysis, and the two related factors may contribute to the occurrence of cardiovascular events.

Key words: Continuous ambulatory peritoneal dialysis, B-type natriuretic peptide, Advanced oxidation protein product, Malondialdehyde, Superoxide dismutase