Abstract: 【Abstract】 Objective To determine the correlation between 25-hydroxy vitamin D (25(OH) D) deficiency and anemia in a cohort of hemodialysis (HD) patients. Methods In this cross-sectional study, we assessed the levels of 25(OH) D, hemoglobin (Hb) and C-reactive protein (CRP) in 116 HD patients in a dialysis center (Kidney Disease Center, Shanghai Changhai Hospital). Patients were classified into three groups according to the level of 25(OH)D: ＜5 ng/ml (n=32), >5 and 15 and ＜30 ng/ml. We compared hemoglobin and CRP levels among the three groups. Results In the HD patients, hemoglobin was positively correlated with 25(OH)D (r=0.367, P＜0.01) in a linear fashion, meanwhile CRP was negatively correlated with 25(OH)D (r=-3.123, P＜0.01). Conclusion The evidence that 25(OH)D deficiency was independently associated with the lower hemoglobin level in HD patients may have clinical significance.

Key words: Hemodialysis, 25-OH vitamin D, Anermia