Abstract: 【Abstract】Objective To explore the usefulness and safety of single bed mobile dialysis water treatment system for maintenance hemodialysis (MHD) children with end stage renal disease (ESRD) in China. Methods The portable water treatment system is composed of three parts: water pretreatment, water softening and reverse osmosis, producing pure water for hemodialysis. We examined the quality of water from the system and retrospectively reviewed the dialysis adequacy, complication and outcome of 20 MHD children using the water for dialysate in our center during the period from Aug. 2010 to Mar. 2014. Results ①Water quality indices including endotoxin level, bacteria count and heavy metal content were consistent with the criteria of standard operation procedure (SOP) for blood purification issued by Chinese Ministry of Health. Endotoxin level in dialysis water decreased further after improvement of the water pretreatment device beginning from May 2013. Endotoxin reduced to <0.5 EU/ml in all water samples and to <0.25 EU/ml in 88% samples. ②No fever reaction, hemolysis, hard water syndrome and other water related complications occurred in the 20 MHD children using the water for hemodialysis dialysate. In the 20 children, dialysis Kt/V was 1.2±0.23 and urea reduction rate was 66.68±7.32%. After 6 months, 12 months and 18 months of HD therapy, the rate of hemoglobin
achieved to the recommended level was 66.7%, 60% and 87.5%, respectively.③ At the end of follow- up, patient survival rate was 100%, 11 cases returned to normal school during MHD therapy, and 4 cases received renal transplantation. Conclusion The quality of dialysis water produced by the portable water
treatment system conformed to the standard of dialysis water and was even superior to the criteria of SOP rec-ommendation. This water treatment system i suitable for children with MHD treatment in China, especially in centers with a small number of hemodialysis patients.

Key words: portable water-treatment system, children, end stage renal disease, hemodialysis