Abstract: Objective To determine whether the lock solution of amikacin sulfate/dalteprin sodium injection can prevent catheter- related complications. Methods This was a randomized, prospective and controlled study. Amikacin sulfate/dalteprin sodium injection was applied into catheter lumen in experimental group (n=20), and dalteprin sodium injection was used as the lock solution in control group (n=20). They all received hemodialysis 3 times a week for 3 months. The incidences of catheter-related complications and other adverse reactions were recorded. Results Catheter- related complications including bacteremia, catheter dysfunction, and thrombosis in catheter were lower in experimental group than in control group (P＜0.05). In experimental group, blood flow, Kt/V, hs-CRP and hemoglobin also improved as compared with those before experiment. There were no other adverse reactions in the two groups. Conclusion The lock solution containing
amikacin sulfate/dalteprin sodium injection can effectively reduce catheter-related complications and improve dialysis adequacy.

Key words: Amikacin sulfate, Dalteprin Sodium Injection, Hemodialysis, tunnelled-cuffed indwelling catheter