Abstract: Objective To observe the condition of conjunctival and corneal calcification refractory secondary hyperparathyroidism (SHPT) patients，and explore the relationship between conjunctival and corneal calcification (CCC)，abdominal aortic calcification (AAC) and cardiac valve calcification (CVC). Methods
CCC was evaluated by slitlamp eye photographs，and was graded and scored according to Porter’S classification system in the literature．Abdominal lateral X-ray examination were used as criteria to determine the AAC．The AAC score was calculated．Echocardiographic was applied evaluate CVC. Spearman correlation coefficient was used to analyze the relationship between CCC and AAC, CVC．Single factor analysis of variance was used to determine the influence factor of CCC in refractory SHPT patients． Results Forty-three refractory SHPT patients were recruited．Their average age were (49.51±9.66) years and dialysis age were 96 (12，204) months . The CCC was positively correlated with AAC (r=0．337，P＜0.05)，the CCC was positively correlated with CVC (r=0.321，P＜0.05)． As for age (t=- 2.258，P=0.029), smoking history (t=- 2.332，P=0.025)and CVC score (t=-2.835，P=0.007), there were statistically significant difference between the patients in AAC＜5 group and AAC acuity group (all P＜0.05);There was statistically significant difference between the CVC score ＜1 group and CVC＞ 1 group in age (t=-2.283，P=0.028), dialysis age (t=-2.235，P=0.023), blood phosphorus (t=2.927，P=0.006), urea (t=2.330，P=0.025), uric acid (t=2.541，P=0.015), blood HDL (t=-2.634，P=0.012), and AAC score (t=-2.595，P=0.013). Single factor analysis of variance showed that the score of AAC (F=6.803，P=0．003)、CVC (F=6.227，P=0.004)、Smoking history (F=3.334，P=0.046) and Dialysis age (F=4.772，P=0.014) were significant impact on CCC． Conclusions Coniunctival and corneal calcification is common in refractory SHPT patients，and CCC is positively associated with AAC and CVC , The risk of CCC will increase as a result of severer AAC、CVC and dialysis age．

Key words: Refractory secondary hyperparathyroidism, Corneal and conjunctival calcification, Abdominal aortic calcification, cardiac valve calcification