Abstract Objective To investigate the maintenance hemodialysis (MHD) patients with chronic periodontal disease . This intervention study was designed to evaluate the effects of non-surgical periodontal therapy on the clinical response and systemic status of MHD patients. and to explore its possible mechanism of influence. Methods Choosing 85 patients with MHD，and other 85 adults from healthy controls group. Record the general conditiongs, have the correlation analysis on periodontal disease index(PDI) and hs-CRP of the patients with MHD. The 40 patients with moderate or severe chronic periodontal disease were treated with non surgical periodontal therapy. The patients were treated with baseline and 1 and 3 months after treatment. The serum hs-CRP was measured by enzyme-linked immunosorbent assay. Results The MHD patients with periodontal disease prevalence rate was 83.5%, debris index (DI) 2.1 (1.2), calculus index (CI) 1.5 (0.8), PDI 3.9 (1.9) were higher than those of healthy control group (P < 0.05). In moderate and severe periodontal disease group, the level of hs-CRP 16 + 6.9mmol/L was higher than that of periodontal health and mild periodontal disease group 11.1 + 7.4mmol/L (P < 0.05). Periodontal clinical parameters and hs-CRP levels were significantly lower in patients with MHD after non-surgical periodontal therapy (P < 0.05). Conclusions Non-surgical periodontal therapy could decrease the local and systemic inflammatory state of MHD patients with chronic periodontal disease, which is beneficial to prevent and treat micro-inflammation of dialysis.