Abstract: Objectives Three different molecular weights of glucose polymers, namely large, medium, and small were prepared. Using New Zealand rabbit model for peritoneal dialysis (PD), the effect of those glucose polymers peritoneal dialysis fluids on the net ultrafiltration and the capacity of creatinine and urea nitrogen
removal and its effect on peritoneal biocompatibility were evaluated. Methods In pharmacological experiment, healthy New Zealand white rabbits were randomly divided into three groups, i.e. low, middle and high molecular glucose polymer PD groups (8 animals in each group). After dwelling of the dialysate for 240 min, blood and effluent fluids were collected, and the concentration of creatinine and urea nitrogen in plasma and effluent fluids were measured. Furthermore, the effect of middle molecular weight glucose polymer for three consecutive days on peritoneal histomorphology was evaluated for biocompatibility study. Results
Three different molecular weights of glucose polymers were developed by controlling synthesis conditions and the glucose polymer peritoneal dialysis fluids were prepared. In vivo studies showed that there were statistically differences in net ultrafiltration (F=8.875, P=0.002), urea nitrogen clearance (F=13.090, P< 0.001), and creatinine clearance (F=6.429, P=0.007) among the three groups. In addition, the middle molecular had a higher ultrafiltration efficiency (63±9 ml vs. 45±8 ml, q=5.910, P=0.001, compared to low moelcular; 63±9 ml vs. 52±8 ml, q=3.612, P=0.047, compared to high molecular) and the better clearance of urea nitrogen (0.485± 0.051 ml/min vs. 0.372±0.046 ml/min, q=6.562, P<0.001, compared to low molecular; 0.485±0.051 ml/min vs. 0.383±0.049 ml/min, q=5.923, P=0.001, compared to high molecular) and creatinine (0.536±0.064 ml/min

Key words: Glucose polymer peritoneal dialysis fluid, Ultrafiltration, Urea Nitrogen Clearances, Creatinine Clearance