Abstract: Objective To study the prognosis of hyperlipidemic acute pancreatitis in pregnancy (HLAPIP) patients treated by continuous veno- venous hemofiltration (CVVH) or CVVH plus plasma exchange (PE). Methods We recruited 30 patients diagnosed with HLAPIP in Luoyang Central Hospital, Zhengzhou University and randomly divided them into 2 groups. The CVVH group received CVVH for 5 days, and the CVVH+PE group received plasma exchange 3 times in addition to CVVH5 for 5 days. We then compared treatment efficiency, symptom alleviating time, fasting time, hospitalization days and laboratory blood indices between the two groups. Results The treatment efficiency is 93.33% in CVVH + PE group, higher than 53.33% (P=0.035) in CVVH group. The symptom alleviating time (t =3.850, P＜0.001), fasting time (t =5.290, P＜0.001), hospitalization days (t =4.890, P＜0.001) are shorter in CVVH+PE group than in CVVH group. After the treatment, white blood cell (t =4.870, P＜0.001), C response protein (t=10.390, P＜0.001), triglyceride (t =5.230, P＜0.001) and total cholesterol (t =5.370, P＜0.001) are lower in CVVH+PE group than in CVVH group; while amylase and lipase have no significant differences between the two groups.

Key words: continuous veno-venous hemofiltration, plasma exchange, pregnancy, hyperlipidemic acute pancreatitis