Abstract: 【Abstract】Objective To analyze the effects of continuous blood purification (CBP) and infection management on plasma inflammatory mediators and electrolytes in AIDS patients complicated with systemic inflammatory response syndrome (SIRS) and acute renal failure. Methods A total of 30 AIDS patients complicated with SIRS and acute renal failure treated in our hospital from January 2012 to December 2015 were enrolled in this study. After admission they were closely monitored and treated with the routine management. They were treated with CBP through right jugular vein. The effects of infection management were determined according to the diagnostic criteria for hospital infection, and their therapeutic effects were estimated by comparison of plasma inflammatory mediators before and after the therapy. Results After CBP for 2 hours and 6 hours, plasma TNF-α, IL-6 and IL-10 decreased significantly (P<0.05, for TNF-α, IL-6 and IL-10 at 2 hours and 6 hours); plasma TNF-α, IL-6 and IL-10 decreased further along with the CBP duration. Plasma BUN, K, Na, Cl and glucose decreased after CBP for 2 hours and 6 hours (P＜0.05, for BUN, K, Na, Cl and glucose at 2 hours and 6 hours). Plasma BUN and K after CBP for 6 hours were lower than those after CBP for 2 hours (P＜0.05). In the 30 patients treated with CBP, 11 patients died and 19 patients survived with the survival rate of 63.3%. Conclusion For AIDS patients complicated with SIRS and acute renal failure, nosocomial infections could be reduced significantly through standardized management of nosocomial infections, and their abnormal levels of plasma inflammatory mediators, imbalance of electrolytes, derangement of homeostasis and renal failure could be improved by CBP.

Key words: systemic inflammatory response syndrome, renal failure, continuous blood purification, infection, inflammatory mediators