Abstract: 【Abstract】Objective To investigate the relationship between depression and dialysis- related clinical and biochemical parameters in maintenance hemodialysis (MHD) patients by using a cross- sectional study. Methods A total of 80 MHD patients compliant with the inclusion criteria and selected by the convenience sampling method were enrolled in this study. Their depression degree was evaluated by the Beck depression inventory (BDI), and their dialysis-related clinical and biochemical parameters in the recent one month were collected. They were then divided into depression group and non-depression group according to the BDI results. Chi-square test and independent-sample t test were used to compare the baseline characteristics and dialysis-related clinical and biochemical parameters between the two groups. Logistic regression was used to analyze the protective and risk factors for depression. Results A total of 75 patients completed the trial, including 53 cases in depression group and 22 cases in non- depression group, with the depression morbidity of 70.67%. There were no differences in age, dialysis vintage, gender, educational level and disease cause between the two groups (P>0.05). In non-depression group before dialysis, blood platelet (t=3.466, P=0.001), serum total protein (t=2.462, P=0.016), albumin (t=2.833, P=0.006), creatinine (t=2.547, P=0.013), calcium (t=2.938, P=0.004) and body mass index (BMI, t=2.582, P=0.012) were significantly higher than those in depression group, and alkaline phosphatase (t=-2.742, P=0.008), spKt/V (t=-2.127, P=0.037) systolic blood pressure (t=-4.385, P<0.001) and diastolic blood pressure (t=-3.168, P=0.002) were significantly lower than those in depression group. Logistic regression showed that higher interdialytic systolic blood pressure (OR=1.272, 95% CI: 1.031～1.568, P=0.025) was the independent risk factor for depression in MHD patients, and higher predialytic serum albumin (OR=0.552, 95% CI: 0.332～0.919, P = 0.022), creatinine (OR = 0.994, 95% CI: 0.990～0.999, P = 0.018), calcium (OR<0.001, 95% CI: 0～0.054, P = 0.006) and BMI (OR = 0.383, 95% CI:
0.189 ～0.777, P=0.008) were the independent protective factors for depression in MHD patients. Conclusion The prevalence of depression was higher in MHD patients. Interdialytic systolic blood pressure was the independent risk factor for depression in MHD patients, while higher predialytic serum albumin, creatinine, calcium and BMI were the protective factors for depression in MHD patients.

Key words: maintenance hemodialysis patients, depression, dialysis-related clinical and biochemical parameters