Abstract: 【Abstract】Objective To investigate the effect of hemoperfusion and double- filtration plasmapheresis for the treatment of hyperlipidemia in severe acute pancreatitis patients. Methods Fifty patients diagnosed as severe acute pancreatitis with hyperlipidemia between January 2016 and April 2018 were randomly divided into hemoperfusion (HP) group and double-filtration plasmapheresis (DFPP) group. Results HP group and DFPP group were comparable in terms of gender, age, body mass index (BMI), acute physiology and chronic health evaluation II (APACHE Ⅱ) score and blood lipid levels at admission. There were also no statistical differences in complications, changes of abdominal CT images, and number of death between the two groups. The medical expense of DFPP was higher than that of HP. The mean decrease percentages of plasma triglyceride (TG) and total cholesterol (TC) after one treatment were 60.1% and 37.0%, respectively, in HP group and were 63.2% and 41.8%, respectively, in DFPP group. In HP group before and after the treatment, plasma TG
levels were (47.08±35.8)mmol/L and 17.49±20.37 mmol/L, respectively (t=4.124, P=0.001), and TC levels were (13.52±5.90)mmol/L and 10.01±6.11mmol/L, respectively (t=5.737, P=0.000). In DFPP group before and after the treatment, plasma TG levels were (44.42±42.30)mmol/L and (16.31±17.68)mmol/L, respectively (t=3.298, P=0.011), and TC levels were (18.29 ± 16.13) mmol/L, and (9.73 ± 7.17)mmol/L, respectively (t= 2.656, P=0.029). There were no differences in the decrease of TG [(18.55±21.99)mmol/L in HP group and (16.31 ± 17.68)mmol/L in DFPP group, t=0.207 P=0.084] and TC [(10.78 ± 6.27)mmol/L in HP group and (9.37±7.17)mmol/L in DFPP group, t=0.272 P=0.792] between the two groups. Conclusions Both HP and DFPP reduced TG and TC levels. Moreover, HP and DFPP had comparable effects on lowering blood lipid levels.

Key words: Severe acute pancreatitis with hyperlipidemia, Hemoperfusion, Double-filtration plasmapheresis, APACHE Ⅱscore