Abstract: 【Abstract】Mitophagy specifically regulates autophagosome to engulf, degrade and eliminate damaged mitochondria, which is a repair mechanism of mitochondrial injury and plays an important role in maintaining mitochondrial function and cell survival. Mitophagy can also promote cell differentiation and
decrease senility. Recently, mitophagy is widely studied in tumors, nervous system diseases and heart diseases. Mitophagy is a hot topic in kidney disease research. The purpose of this review is to give a brief introduction of the mechanism and physiological function of mitophagy and the recent advances in mitophagy in kidney diseases.

Key words: mitophagy, chronic kidney disease, acute kidney injury, senescence