Abstract: 【Abstract】Objectives To investigate the clinical characteristics and outcome of end- stage renal disease (ESRD) children treated with peritoneal dialysis (PD) and hemodialysis (HD). Methods Clinical data of ESRD children who received PD or HD in Children’s Hospital of Fudan University from January 2011 to
June 2018 were collected. Clinical parameters, ESRD complications, time to transplantation and outcome were compared between PD and HD groups. Results A total of 231 cases who received PD and 50 cases who received HD were enrolled in this study. The mean age was younger in PD group than in HD group (t=-4.998, P＜0.001). There were no significant differences in parameters during dialysis period, including hemoglobin (t=0.560, P=0.576), serum calcium (t=0.000, P=1.000) and phosphate (t=0.448, P=0.657), PTH (t=-1.828, P=0.069) and left ventricular mass index (Z=-0.750, P=0.455). The time to transplantation (t=-0.733, P=0.467) and outcome (P=0.334) were similar between PD and HD groups. Conclusion Most cases (82%) received PD as the first dialysis modality. ESRD complications, time to transplantation and outcomes were similar for children initiated on PD or HD therapy.

Key words: peritoneal dialysis, hemodialysis, children, end-stage renal disease, outcome