Abstract: 【Abstract】Renal osteodystrophy is one of the common and serious complications in CKD patients, leading to a significant increase in fracture risk and morbidity and seriously affecting the quality of life. Sclerostin is a glycoprotein expressed by bone cells, affects bone growth and metabolism at all stages, and participates in the pathogenesis of renal osteodystrophy. This review introduces the advances in the study of sclerostin in renal osteodystrophy.

Key words: Chronic kidney disease, Renal osteodystrophy, Sclerostin