Abstract: 【Abstract】Objective To systematically evaluate the effect of online hemodiafiltration (OL-HDF) on quality of life of maintenance hemodialysis (MHD) patients. Methods We used computer to search for the random and control studies about the effect of OL-HDF on quality of life of MHD patients during the period from the establishment of the databases to Aug. 30, 2019 in PubMed, Web of Science, Cochrane library, CNKI, VIP and Wan fang databases. Literature screening, data extraction, and the bias assessment of all eligible studies were independently conducted. RevMan 5.3 software was used for meta analyses. Results A total of 12 random and controlled trials involving 17,728 patients were included.The results showed thatOL-HDFcould improve the negative emotions (SMD=1.112, 95%CI 0.081~2.142, P=0.040) and social activity (SMD=0.467, 95% CI 0.032~0.886, P=0.042) in MHD patients. OL-HDF showed no significant differences in physiologyrelated quality of life (SMD=- 0.051, 95% CI - 0.155~0.053, P=0.332), psychology- related quality of life (SMD=-0.041, 95% CI -0.141~0.076, P=0.483) and fatigue (SMD=0.352, 95% CI -0.469~1.163, P=0.403), as compared those in patients with conventional hemodialysis. Conclusions OL-HDF has better effects on improving negative emotion and social activities in MHD patients. However, there are no significant differences in physiology and psychology-related quality of life and fatigue between patients with OL-HDF and conventional
hemodialysis.

Key words: Renal dialysis, Quality of life, Systematic review, Meta-analysis