Abstract: 【Abstract】Objective To analyze the relationship between bone mineral density and the related clinical parameters, and to explore the risk factors for osteoporosis in maintenance hemodialysis (MHD) patients. Methods A total of 102 MHD patients treated in the Department of Nephrology, Baoji People's Hospital were retrospectively analyzed. Bone mineral density (BMD) of calcaneus was measured by quantitative ultrasound examination and expressed as T score. According to T score, the patients were divided into three groups: normal bone mass group (T score ≥-1.0), reduced bone mass group (-2.5＜ T score ＜-1.0), and osteoporosis
(T score ≤-2.5) group. Clinical parameters were compared among the three groups. The correlation between T score and clinical parameters was analyzed. Results Among the 102 MHD patients, 41 patients (40.2%) were divided into osteoporosis group, 50 patients (49.0%) in reduced bone mass group, and 11 patients (10.8%) in normal bone mass group. There were statistical differences in age (F=5.054, P=0.032), 25-hydroxyvitamin D level (F=18.131, P=0.009) and the index of osteoporosis self-assessment tool for Asians (OSTA) (F=5.714, P=0.043) among the three groups. Pearson correlation analysis showed that T score was negatively correlated with age (r=-0.412, P=0.033) and positively correlated with 25-hydroxyvitamin D level (r=0.596, P= 0.021) and OSTA index (r=0.387, P=0.046). Multivariate stepwise regression analysis showed that 25-hydroxyvitamin D level was the main factor affecting T score of BMD (t=6.214, P＜0.001). Conclusions The incidence of osteoporosis was higher in MHD patients. The main risk factor for osteoporosis was 25-hydroxyvitamin D insufficiency.

Key words: Hemodialysis, Osteoporosis, Bone mineral density, Quantitative ultrasound