Abstract: 【Abstract】Objective To observe the clinical effects of double plasma molecular adsorption system in the treatment of hyperbilirubinemia patients and to investigate the optimal adsorbed plasma volume. Methods A retrospective analysis was performed for the 18 patients with hyperbilirubinemia treated with double plasma molecular adsorption system in the Seventh People's Hospital of Shanghai University of Traditional Chinese Medicine. Patients were grouped according to the total plasma adsorption volume in a single treatment. Their laboratory indicators including blood routine, coagulation function, and liver and kidney functions before and after the treatment were analyzed. Results A total of 24 times of double plasma molecular adsorption
systems were used in the 18 patients, of which 2 cases were markedly effective, 15 cases were effective, and one case was ineffective, with a total effective rate of 94.44%. After the treatment, serum total bilirubin (t=16.424, P＜0.001), direct bilirubin (t=4.324, P＜0.001), platelet count (t=5.124, P＜0.001) plasma fibrinogen (t=2. 237, P=0.039) and C-reactive protein (t=3.519, P=0.003) decreased, and prothrombin time increased (t=0.245, P=0.041). The ratio of total adsorbed plasma volume in a single treatment to total plasma volume in normal individuals (4000 ml) was used to divide the patients into 5 groups: 1.5～2.5 times, 2.5～3.5 times, 3.5～4.5 times, 4.5～5.5 times and 5.5～6.5 times groups. The rate of the total bilirubin reduction was higher in 2.5～3.5 times group than in 1.5～2.5 times group (t=-2.633, P=0.017), but had no significant differences among other groups (P＞0.05). Conclusion The double plasma molecular adsorption system was effective in treating hyperbilirubinemia. The total adsorbed plasma volume in a single treatment in the range of 2.5 to 3.5 times of total plasma volume will have a better therapeutic effect.

Key words: Double plasma molecular adsorption system, Bilirubin, Adsorb, Therapeutic effect