Abstract: 【Abstract】Objective Evaluation of malnutrition and inflammation after parathyroidectomy in 23 patients with maintenance hemodialysis(MHD). Methods 23 MHD patients with parathyroidectomy were enrolled. Then, we observed the changes of dry weight, serum calcium, phosphate, intact parathyroid hormone (iPTH), hemoglobin, hematocrit, serum albumin, total iron binding capacity, and Malnutrtion- inflammation score (MIS) was calculated at 12 months after parathyroidectomy. Results Compared with condition before parathyroidectomy, patients’dry weight, hemoglobin, hematocrit and serum albumin increased significantly at 12 months after parathyroidectomy [(52.2±5.41)kg vs.(57.5±6.6)kg, t=-2.964, P=0.005;(89.5±8.3)g/L vs.(102.5±7.1)g/L, t=- 5.716, P=0.000; (31.1±3.1)% vs. (38.7±4.1)%, t=- 6.975, P＜0.001; (31.2±4.2)g/L vs. (40.2±4.7)g/L, t=-6.865, P=0.000]. The levels of calcium, phosphate and iPTH decreased significantly [(2.85±0.17) vs. (2.10±0.42)mmol/L, t=7.871, P＜0.001; (1.99±0.26) vs. (1.13±0.17)mmol/L, t=13.432, P＜0.001;(1536.0±252.0) vs. (144.4±41.9)ng/L, t=26.136, P＜0.001]. Meanwhile, the level of C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and MIS decreased significantly at 12 months after parathyroidectomy [(10.2±1.8)ng/dl vs. (4.1±1.2)ng/dl, t=13.583, P＜0.001; (65.8±16.7) pg/ml vs. (42.6±13.9)pg/ml, t=5.125, P＜0.001; (49.6±13.7)pg/ml, vs. (34.6±8.517)pg/ml, P＜0.001; (11.80±2.43)scores vs. (6.35±2.50)scores, t=7.480, P＜0.001). Conclusion Total parathyroidectomy can effectively improve the status of malnutrition and inflammation in MHD patients. Further, these will be beneficial to improve the quality of life in MHD patients with secondary hyperparathyroidism.

Key words: Hemodialysis, Secondary Hyperparathyroidism, Parathyroidectomy, Malnutrition, Inflammation