Abstract: 【Abstract】Objective To investigate the risk factors influencing peritoneal dialysis (PD) patients to reach the target hemoglobin (Hb) level. Methods PD patients treated in the General Hospital of Ningxia Medical University during the period from May 2003 to October 2015 and followed up for more than one year were retrospectively analyzed. Based on the Hb level at the end of follow-up period, they were divided into targeted group (Hb≥110g/L) and non-targeted group (Hb＜110g/L); patients in the non-targeted group were further divided into mild anemia subgroup (90g/L≤ Hb <110g/L) and moderate or severe anemia subgroup (Hb＜90 g/
L). The risk factors influencing peritoneal dialysis (PD) patients to reach the target Hb level were obtained through the comparison of clinical characteristics between targeted group and non-targeted group and between the two subgroups. Results ①A total of 267 PD patients were enrolled in this study. In this cohort of PD patients, 59.93% were males, the mean age was 52 years old, the median PD vintage was 37 months, the mean follow-up period was 37(21,61) months, the baseline mean Hb level was 80.16± 14.89g/L, and 50.30% of the patients reached the targeted Hb level. ②Patients in non-targeted group had younger age, longer PD vintage, lower rGFR, lower baseline Hb level, higher iPTH level, lower Kt/V and lower erythropoietin dose, as compared with those in the patients in targeted group (t/Z=2.894, -3.757, 4.400, 6.833, 2.364, 3.992 and 1.396 respectively; P=0.004,＜0.001,＜0.001,＜0.001, 0.019,＜0.001 and 0.041 respectively). ③Patients in mild ane-mia subgroup had younger age, longer PD vintage, lower baseline Hb level, rGFR, Kt/V and erythropoietin dose, and higher iPTH as compared with those in the patients in targeted group (t/Z=2.021, - 2.768, 6.193, 2.515, 3.729, -2.336 and -2.312 respectively; P=0.044, 0.006, ＜0.001, 0.013, ＜0.001, 0.019 and 0.021 respectively); similar results could also be found when the comparisons were made between moderate or severe anemia subgroup and targeted group. ④ Multivariate logistic regression analysis showed that female (OR= 0.416, P=0.021), younger age (OR=1.019, P=0.003), inadequate dialysis (OR=0.285, P＜0.001) and hypoalbuminemia(OR=0.942,P=0.027)were the independent risk factors for unable to reach the target Hb level. Conclusions Female, younger age, inadequate dialysis and hypoalbuminemia were the independent risk factors for failure to reach the target Hb level.

Key words: Peritoneal dialysis, Anemia, Hemoglobin