Abstract: 【Abstract】Objective To assess the status and related factors of abdominal aorta calcification (AAC) and cardiac valve calcification (CVC) in end stage renal disease (ESRD) patients. Methods A total of 277 ESRD patients admitted to the Department of Nephrology, Cangzhou Central Hospital from October, 2019 to December, 2020 were enrolled in this study. They were divided into AAC group and non-AAC group, CVC group and non-CVC group, AAC and CVC group and non-AAC and non-CVC group, based on AAC score and CVC status. Clinical characteristics and related factors were compared among the groups. Results The rates of elderly, female, diabetes, coronary atherosclerotic heart disease (CHD), peritoneal dialysis (PD), CVC and higher C-reactive protein (CRP) level were significantly higher in AAC group than in non-AAC group (P＜0.001, ＜0.001, =0.002, =0.001, =0.042, ＜0.001 and =0.005 respectively). More elderly, diabetes, CHD, and higher diastolic blood pressure, mean arterial pressure, platelet and AAC score were found in CVC group (P＜0.001,＜0.001,＜0.001,＜0.001, =0.001, =0.006 and ＜0.001 respectively). The rates of elderly, diabetes, CHD, higher diastolic blood pressure, higher serum phosphorus increased in AAC and CVC groups (P＜0.001, ＜0.001, ＜0.001, ＜0.001 and =0.001 respectively). Multivariate logistic regression showed that age and dialysis were the independent risk factors for AAC, that age, white blood cell, history of diabetes and CHD, and AAC score were the independent risk factors for CVC, and that age and PD were the independent risk factors for both AAC and CVC. Conclusions AAC and CVC were clinically correlated. However, clinical characteristics and related factors of the two vascular calcifications were different. Active prevention, treatment and individualized management are required.

Key words: Aorta abdominalis calcification, Cardiac valve calcification, End stage renal disease