Abstract: 【Abstract】Indoxyl sulfate (IS), a typical uremia toxin, is the product of tryptophan decomposed by intestinal flora and then by a series of metabolic processes. Its binding rate with plasma albumin was more than 90%. In chronic kidney disease (CKD), IS cannot be effectively secreted and excreted through the impaired renal tubules. More evidences have shown that IS plays a key role in the presence and development of uremic complications and is also related to the prognosis of uremic patients. Therefore, the clearance of IS is particularly important. Here we summarize the recent advances in the clearance of IS by blood purification.

Key words: Indoxyl sulfate, Chronic kidney disease, Blood purification