Abstract: 【Abstract】Serum calciprotein particles (CPPs) are present in the form of colloidal nanoparticles in serum and have become a novel biological marker for chronic kidney disease-mineral and bone disorder (CKDMBD). CPPS are now intrigued by its involvement in the pathogenesis of vascular calcification in CKD patients. This article reviews the basic structure and biological activities of CPPs as well as the relationship between CPPs and vascular calcification, so as to provide a new diagnostic marker and therapeutic target for vascular calcification in CKD patients.

Key words: Calciprotein particles, Vascular calcification, Chronic kidney disease