Abstract: Wearable artificial kidney (WAK) is an evolutionary product of dialysis equipment. The key to develop WAK is to remove uremic solutes from waste dialysis fluid, in which urea is the most difficult uremic solute to be cleared. After investigating the progresses of urea removal technology of WAK in China and foreign countries, this paper reviews the urease urea removal technology, electrooxidation technology and urea adsorption technology. Their principles are briefly introduced, and the urea removal effects in clinical trials of WAK are analyzed. Finally, the advantages and disadvantages of the three technologies are evaluated and prospected. It is expected to provide relevant support and reference information of WAK to the urea removal technology researchers.

Key words: Wearable artificial kidney, Urea, Urease, Electrooxidation, Adsorption