Abstract: Objective   To investigate the clinical significance of changes of serum parathyroid hormone (PTH), serum ferritin (SF) and Th22/Treg cells in uremic patients with hemodialysis.   Methods   A total of 65 uremia patients undergoing hemodialysis from January 2020 to January 2021 and treated in The First People’s Hospital of Jiangxia District Wuhan City were retrospectively reviewed. Their serum PTH, SF and inflammatory factors, and Th22/Treg cells were recorded. The correlation between Th22/Treg cells and serum levels of PTH, SF and inflammatory factors and the predictive value of Th22/Treg cells for micro-inflammatory state in these hemodialysis patients were evaluated.  Results  In uremic patients after hemodialysis for 3 and 6 months, serum SF levels were (132.34±20.77)ng/ml and (201.92±25.80)ng/ml respectively, higher than the serum SF of (85.49±15.34)ng/ml in control group (t=14.628 and 31.273, P=0.001); serum PTH levels were (153.92±15.48)pg/ml and (238.60±19.44)pg/ml respectively, higher than the serum PTH of (30.43±10.95)    ng/ml in control group (t=50.507 and 74.221, P=0.000); Th22 cell ratios were (1.15±0.26)% and (1.35±0.24)%, higher than the ratio of (0.97±0.20)% in control group (t=4.424 and 9.807, P=0.001); Treg cell ratios were (1.46±0.19)% and (1.25±0.19)%, lower than the ratio of 1.86±0.24% in control group (t=10.535 and 17.050, P=0.001).  Conclusion   In uremic patients undergoing hemodialysis, serum PTH, serum SF and Th22 cell ratio increased, while Treg ratio decreased. These abnormalities are related to the micro-inflammatory state of the patients. Th22/Treg may be regarded as the predictor factors for micro-inflammatory state in hemodialysis patients.

Key words: Uremia, Hemodialysis, Parathyroid hormone, Inflammatory response