Abstract: Objective   To explore the maintenance effect of HA380 hemoperfusion combined with continuous veno-venous hemodiafiltration (CVVHDF) on liver function of septic shock donors, in order to improve the utilization rate of liver of septic shock donors. Methods  The clinical data of 33 septic shock donors who successfully donated organs in our hospital from November 2020 to November 2022 were retrospectively analyzed. All of them received HA380 combined with CVVHDF for organ function maintenance treatment, and the changes of inflammatory reaction and liver function indexes of septic shock donors before and after treatment were observed. Results  Compared with before treatment, the levels of white blood cell count (WBC), C-reactive protein (CRP), procalcitonin (PCT), interleukin -6 (IL-6) and total bilirubin (TB) of septic shock donors decreased after treatment (t=12.462, 6.252, 6.995, 3.305, 6.360, P＜0.001). There was no significant difference in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) among donors with septic shock before and after treatment (t=0.035,0.930, P=0.972, 0.356).  Conclusion  HA380 combined with CVVHDF technology is effective in organ maintenance of septic shock donors, which can reduce inflammatory reaction, improve the quality of donor liver and organ function, and improve the organ utilization rate of donors to some extent.

Key words: Septic shock, Organ donation, Hemoperfusion, Continuous veno-venous hemodiafiltration, Organ maintenance