Abstract: Objective  To investigate the relationship between peripheral blood cyclophilin A (CyPA) level and vascular calcification and prognosis in patients with end-stage kidney disease (ESKD).  Methods  A total of 240 patients with ESKD admitted to the hospital from April 2020 to May 2024 were selected as the research objects, including 156 patients in the vascular calcification group and 84 patients in the non-calcification group. Blood CyPA level, serum calcium (Ca2+), serum phosphorus (P3-), Ca2+ x P3- product, C-reactive protein (CRP), serum creatinine (Scr) and blood lipid were compared between vascular calcification group and non-calcification group and between survival group and death group to correlate these indexes with vascular calcification and death.  Results  P3-(t=4.140, P＜0.001), Ca2+×P3- product (t=34.168, P＜0.001), CRP (t=40.459, P＜0.001), CyPA (t=14.743, P＜0.001), PTH (t=15.737, P＜0.001) and albumin (t=33.470, P＜0.001) were statistically different between vascular calcification group and non-calcification group. P3-(t=15.916, P＜0.001), Ca2+×P3- product (t=25.969, P＜0.001), CRP (t=26.705, P＜0.001), CyPA (t=9.757, P＜0.001), PTH (t=206.716, P＜0.001) and albumin (t=57.496, P＜0.001) were statistically different between survival group and death group. Multivariate analysis showed that P3- (OR=0.313), Ca2+×P3- (OR=0.320), CRP (OR=0.299), CyPA (OR=0.362), PTH (OR=0.343) and albumin (OR=3.271) were the risk factors for vascular calcification, while P3- (OR=0.339), Ca2+×P3- product (OR=0.351), CRP (OR=0.345), CyPA (OR=0.303), PTH (OR=0.336) and albumin (OR=2.965) were the risk factors for death.  Conclusion  Peripheral blood CyPA level is significantly correlated with vascular calcification and survival in ESKD patients. Therefore, blood CyPA level can serve as an important indicator for the assessment of clinical diagnosis and prognosis.

Key words: Peripheral blood CyPA, End-stage kidney disease, Prognosis, Correlation