Abstract: Objective To analyze the risk factors for sarcopenia in patients with maintenance hemodialysis (MHD), so as to explore the preventive measures and the basis for reducing the incidence of sarcopenia in MHD patients.  Methods A total of 312 MHD patients admitted to the Sixth People's Hospital Affiliated to Shanghai Jiaotong University from December 2020 to September 2023 were included in this study. According to the presence and absence of sarcopenia, they were divided into the concurrent group (82 cases) and the non-concurrent group (230 cases). Univariate and multivariate logistic regression analyses were used to screen the risk factors for sarcopenia in MHD patients.  Results Univariate and multivariate logistic analyses showed that age ≥65 years (OR=1.998, 95% CI: 1.188～3.358, P=0.009), body mass index (BMI) ＜21 kg/m2 (OR=1.870, 95% CI: 1.037～3.374, P=0.038), glomerular filtration rate ＜1 mL/min (OR=2.036, 95% CI: 1.120～3.702, P=0.020), higher total body moisture (OR=1.881, 95% CI: 1.013～3.495, P=0.046), higher serum high sensitivity C-reactive protein (hs-CRP) level (OR=1.802, 95% CI: 1.013～3.495, P=0.031), low grip strength (OR=1.749, 95% CI: 1.082～2.827, P=0.023) and low skeletal muscle mass index (ASMI) (OR=1.944, 95% CI: 1.271～2.977, P=0.002) were the risk factors for sarcopenia in MHD patients.  Conclusion  There are many risk factors for sarcopenia in MHD patients. Clinically, the incidence of sarcopenia in MHD patients can be reduced by prevention and detection of the risk factors.

Key words: Hemodialysis, Sarcopenia, Risk factors