Abstract: Uremic tumoral calcinosis (UTC) is a rare complication of end-stage renal disease, characterized by painless calcium salt deposits around large joints. Its core driving factor is elevated serum phosphate and calcium-phosphate product. Diagnosis requires a combination of dialysis history, clinical manifestations, imaging examinations, and laboratory indicators including serum calcium, phosphate, parathyroid hormone, and alkaline phosphatase. The therapeutic goal is to jointly control serum phosphate, serum calcium, and mineral-bone metabolism. Major approaches include non-calcium-based phosphate binders, low-calcium dialysis, parathyroidectomy, kidney transplantation, and lesion excision. Due to the lack of large-scale controlled studies, the optimal management strategy for UTC remains to be further validated

Key words: Uremic tumoral calcinosis, End-stage renal disease, Soft tissue calcification, Secondary hyperparathyroidism, Calcium-phosphorus product