Abstract: Objective To investigate the effects of fosinopril combined with simvastatin on inflammatory parameters and nutritional status in maintenance hemodialysis (MHD) patients. Methods 127 MHD patients and 26 controls were enrolled. All MHD patients were randomly divided into four groups and followed up for six months. 32 patients of them were treated with fosinopril combined with simvastain (group A), 32 patients of them were treated with fosinopril (group B), 31 patients of them were treated with simvastain (group C), and 32 patients were not given ACEI, ARB and statins (group D). The serum levels of c-reactive protein (CRP), interleukin (IL)-1 , IL-6, tumor necrosis factor- (TNF- ) and nutrition were measured at the experiment onset, three months and six months later.Twenty-six normal medical examination adults who took no medicines were selected as healthy control group. Results At the initiation of the investigation, the serum levels of CRP, IL-1 , IL-6 and TNF- in MHD patients were obviously higher than those in the control group (P＜0.01). After treatment for three months, the scores of CRP, IL-6, TNF- were obviously decreased in group A ,B and C, compared with group D and before treatment (P＜0.05). Six months later, the levels of IL-1 in group A , B and C were also significantly lower than those in group D and baseline (P＜0.05). The serum levels of albumin (Alb) and pre-albumin (PA) in group A and B were increased remarkably (P＜0.05). Except for group C, the longer the duration of the experiment, the more significantly changes of the levels of inflammatory parameters, Alb and PA (P＜0.05). The degree of serum CRP, IL-1 , IL-6 and TNF- in group A were decreased greatly after treatment for six months (P＜0.05), while the degree of serum Alb and PA were increased remarkably (P＜0.05), compared with those in group B and C. Conclusion Using fosinopril combined with simvastain may significantly improved microinflammation parameters and nutrition states in MHD patients than that of using fosinopril or simvastain only.

Key words: Inflammation, Nutrition