Abstract: 【Abstract】Objective To investigate the impact of comorbid conditions on inflammation, nutritional status and outcomes in peritoneal dialysis patients. Method A total 202 peritoneal dialysis patients were studied. Pre-dialysis and post-dialysis comorbid and their outcomes were recorded. Patients were then grouped into high comorbid group, low comorbid group and non comorbid group based on the Charlson Comorbidity Index (CCI). Inflammation, nutritional status and outcomes were compared among the groups.  Result Patients with higher CCI score showed worse malnutrition condition evaluated by SGA, lower serum albumin level, and higher serum CRP (P＜0.05). Kaplan-Meier survival analysis revealed a significant difference in cumulative survival rate among the 3 groups, and the cumulative survival rates were lower in CCI high group and CCI low group than in CCI zero group (χ2=37.048, P＜0.05). Cox regression analysis revealed that CCI, age, SGA and percentage of LBM were independent prognostic indicators (χ2=9.872, 5.836, 7.816 and 15.051, respectively, P＜0.05).  Conclusion Peritoneal dialysis patients with comorbid conditions may accompany with systemic inflammation and malnutrition during peritoneal dialysis, which may explain the increased mortality.

Key words: Peritoneal dialysis, ,Comorbidity, ,Charlson Comorbidity Index, Inflammation, Malnutrition, Survival