Abstract: 【Abstract】 Objective To assess the risk factors for intradialytic-hypotension (IDH) among maintenance hemodialysis (MHD) patients, and to provide clinically useful information for the prevention and treatment of IDH.  Methods We recruited 293 patients who underwent hemodialysis during Jan. 2009 to Dec. 2010. Intradialytic blood pressure was monitored in a 3-month period. IDH was defined as an event characterized by a sudden drop of systolic BP more than 20mmHg or of mean artery pressure (MAP) more than 10mmHg. Logistic regression analysis was used to assess the risk factors for IDH.  Results The incidence rate of IDH was 39.9%. In the 293 patients, 176 patients with <1/10 IDH events/3 months (defined as non-IDH) were served as controls, 80 patients were found to have ≥1/10 but ≤1/3 IDH events/3 months (occasional IDH), and 37 patients with ＞1/3 IDH events/3 months (frequent IDH). We used ultrafiltration volum/body weight (UFV/W) to correlate with IDH, and the area under the ROC curve (AUC) of IDH was 0.706 (95% CI: 0.64～0.77, P<0.01). When the cut-off value of UFV/W was set at 4.33%, the sensitivity for IDH was 53.2% and the specificity for IDH was 76.5%. Multivariate regression analysis showed that age, ultrafiltration rate, serum NT-proBNP, serum albumin, and serum β2MG were associated with IDH among MHD patients.  Conclusion Elderly, higher ultrafiltration rate, higher levels of serum NT-proBNP and β2MG, and hypoalbuminemia are independent risk factors for IDH among MHD patients.

Key words: Intradialytic-hypotension, Risk factors, Ultrafiltration volum/body weight