Abstract: 【Abstract】Objective To analyze the therapeutic effects of parathyroidectomy (PTX) in uremic patients with secondary hyperparathyroidism (SHPT) and different degrees of ectopic calcification. Methods Patients were divided into two groups: group A without specific image of cardiovascular ectopic calcification, and group B with apparent cardiovascular ectopic calcification on X ray and/or ultrasound examinations. Pre- and post-operation symptoms and signs, iPTH, calcium supplementation protocol, cardiovascular events, as well as other indications were observed.  Results Among the 42 SHPT patients that underwent PTX, 17 were enrolled in group A, and 25 patients in group B. In group A after the operation, pruritus and bone pain symptoms were largely relieved, with stable serum calcium level and without the development of adverse cardiovascular events or cardiovascular calcification; in group B, however, the symptoms relieved also after the operation but recurred in 6 patients, and serum calcium levels were lower than those in group A. Seven patients in group A needed to have intravenous calcium administration for more than 6 months. Two patients died of cardiovascular or cerebrovascular events.  Conclusions The prognosis of SHPT patients after PTX is negatively correlated with the severity of vascular ectopic calcification. PTX may help delay the progress of cardiovascular calcification.

Key words: Secondary hyperparathyroidism, Parathyroidectomy, Ectopic calcification