Abstract: Objective To evaluate the cognitive function in patients with different stages of chronic kidney disease (CKD). Methods 103 CKD patients from nephrology department, China Rehabilitation Research Center, Beijing Boai Hospital were enrolled in this study. They were divided into four groups according to eGFR, including CKD1~2 stages group, CKD3~4 stages group, CKD 5 stage non-dialysis group and CKD 5 stage dialysis group. Cognitive function was evaluated by Wechsler Adult Intelligence Scale-Revised by China. Cognitive function in patients with different stages of CKD was compared by using the statistical analysis of one-way ANOVA. Results 103 CKD patients were enrolled. There were 31 patients in the CKD1~2 stages group, the mean age was 54.77±12.70 years; there were 25 patients in the CKD3~4stages group, the mean age was 62.24±14.36 years; there were 10 patients in the CKD5 stage non-dialysis group, the mean age was 60.03 ±12.10 years; there were 37 patients in the CKD5 stage dialysis group, the mean age was 65.00 ±14.41 years; there was a partly decline tendency in cognitive function with eGFR declined. The differences were no statistic significant among the four groups in Full scale Intelligence quotient, Verbal Intelligence quotient and Performance Intelligence quotient（P > 0.05）. Conclusion With the decreasing of eGFR, there was a partly decline tendency in cognitive function in different stages of CKD.

Key words: chronic kidney disease, cognitive function, Wechsler Adult Intelligence Scale-Revised by China